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  5. Nicorandil enhances Na+/Ca2+ exchanger activity via guanylate cyclase activation in cardiac ventricu

Nicorandil enhances Na+/Ca2+ exchanger activity via guanylate cyclase activation in cardiac ventricu

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：nebula_0718
【摘 要】
：
Aim: Nicorandil exhibited cardioprotective and antiarrhythmic effects during the process of ischemia/reperfusion in heart.However, the mechanism through which nicorandil produces these actions remains
【作 者】
：
Jia-zhang WEI Kazuhiko TAKEUCHI Yasuhide WATANABE Hiroshi WATANABE 
【机 构】
：
Department of Clinical Pharmacology and Therapeutics
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
nicorandil Na+/Ca2+exchanger guanylate cyclase myocyte 
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Aim: Nicorandil exhibited cardioprotective and antiarrhythmic effects during the process of ischemia/reperfusion in heart.However, the mechanism through which nicorandil produces these actions remains to be further clarified.Na+/Ca2+ exchanger (NCX) is involved in both the generation of action potential and ischemia/reperfusion-induced Ca2+ overload in cardiac myocytes.Here we investigated the effect of nicorandil on NCX activity.
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