表观遗传修饰因子TET2维持中枢神经系统中神经元的存活

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户：dong770527

【摘要】

：

DNA双加氧酶Ten-Eleven Translocation(TET)是新发现的一类重要的表观遗传修饰因子,其通过将DNA序列中的5-甲基胞嘧啶(5mC)氧化为5-羟甲基胞嘧啶(5hmC),进而调控基因的转录活性.在哺乳动物中,TET家族包括TET1,TET2,TET3.三个成员的羧基段序列含有双加氧酶活性结构域,并且具有高的保守性,而其氨基段序列则差异很大.已有研究报道,TET蛋白在干细胞的干

【作者】

：

米亚静高兴春苟兴春金卫林

【机构】

：

基础医学研究所,西安医学院,西安,710021 生命科学技术学院,上海交通大学,上海,200240

【出处】

：

中国细胞生物学学会2015年全国学术大会

【发表日期】

：

2015年4期

【关键词】

：

TET2 神经元细胞存活中枢神经系统

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表观遗传修饰因子TET2维持中枢神经系统中神经元的存活

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