HMGB1 Modulated Lewis Cells Autophagy and Allowed Cells Survival by Positive Feedback via RAGE-HMGB1

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户:windlam
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Autophagy is a self-digesting mechanism responsible for the removal of long-lived proteins and damaged organelles by the lysosome or for allowing cells to survive during nutrient depletion and/or in the absence of growth factors.Some reports indicated that high-mobility group protein 1 (HMGB 1), a highly conserved nuclear protein, was associated with cells autophagy;however, it was still unclear that HMGB1 how to modulate autophagy.
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