论文部分内容阅读
目的:探讨妊娠期高血压疾病患者24 h尿微量清蛋白水平变化。方法:选择2010年7月～2011年10月正常妊娠者22例(对照组),同期住院妊高征患者61例,其中轻度子痫前期患者27例、重度子痫前期患者34例,采用速率散射比浊法检测24 h尿微量蛋白和24 h尿微量清蛋白。结果:轻度和重度妊高征患者24 h尿微量清蛋白均明显高于正常妊娠孕妇(P<0.001),妊高征重度与轻度相比,24 h尿微量清蛋白增高(P<0.001);重度妊高征患者24 h尿微量清蛋白和24 h微量蛋白阳性率分别为97.10%和100.00%,两项指标无明显差异,轻度组分别为81.50%和55.56%。结论:妊高征患者随病情的加重,24 h尿微量清蛋白及24 h尿微量蛋白水平明显升高,轻度妊娠期高血压疾病患者24 h尿微量清蛋白阳性率高于24 h尿微量蛋白,监测24 h尿微量清蛋白对轻度妊娠高血压的早期诊断和预后具有重要意义。
Objective: To investigate the changes of 24 h urinary albumin in patients with gestational hypertension. Methods: Twenty-two normal pregnant women (control group) from July 2010 to October 2011 were enrolled in the study. 61 cases of PIH during the same period were selected, including 27 cases with mild preeclampsia and 34 cases with severe preeclampsia. The rate of 24 h urinary microalbuminuria and 24 h urine microalbumin were measured by rate nephelometry. Results: 24 h urine microalbumin in patients with mild and severe PIH were significantly higher than those of normal pregnant women (P <0.001). Compared with mild PIH, 24h urine microalbumin increased (P <0.001) ). The positive rates of 24 h microalbuminuria and 24 h microalbuminuria in patients with severe PIH were 97.10% and 100.00%, respectively, with no significant difference between the two groups. The mild group was 81.50% and 55.56% respectively. Conclusions: With the aggravation of disease, the 24-hour urine microalbuminuria and 24-hour urinary microalbumin levels in patients with PIH were significantly increased. The positive rates of 24-hour urine microalbuminuria in patients with mild gestational hypertension were higher than those in 24-hour urinary microalbuminuria Protein, monitoring 24 h urine microalbumin in early diagnosis and prognosis of mild pregnancy-induced hypertension is of great significance.