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随着研究的进展,现已发现白色脂肪组织不仅具有储存能量的功能,而且是全身较为重要的内分泌器官。它可分泌多种蛋白,包括肿瘤坏死因子-α、瘦素、抵抗素、血管紧张素肽、纤溶酶原激活抑制因子-1、脂连素(adiponectin)等,它们具有细胞因子的一些结构特点,因此统称为“脂肪因子”。脂肪因子通过自分泌、旁分泌、内分泌的途径在各种复杂的代谢过程中发挥作用,如糖耐量异常、中心性肥胖、高血压、凝血功能异常等都与脂肪因子有关。自从1995年由Scherer等发现脂连素以来,由于其新的功能不断地被研究和发现,人们对它的认识愈来愈深入,脂连素有望成为人们长期寻找的联系肥胖与胰岛素抵抗的一个重要分子。
With the progress of the research, it has been found that white adipose tissue not only has the function of storing energy, but also the more important endocrine organ in the whole body. It secretes a variety of proteins including tumor necrosis factor-alpha, leptin, resistin, angiotensin-type peptide, plasminogen activator inhibitor-1, adiponectin, etc. They have some of the cytokine Characteristics, so collectively referred to as “fat factor.” Adipokines through autocrine, paracrine, endocrine pathways in a variety of complex metabolic processes play a role, such as impaired glucose tolerance, central obesity, hypertension, coagulation dysfunction and so on are associated with adipokines. Since the discovery of adiponectin by Scherer and others in 1995, adiponectin is expected to become one of the long sought after linkages between obesity and insulin resistance because of its continually being explored and discovered by new features. Important elements.