Silk fibroin/cellulose blend films were prepared using N-methylmorpholine -N-oxide (NMMO) as solvent. The effects of different proportions and solid contents on properties of blend films were discussed. The mechanical properties showed that the blend films had preferable moisture permeability and a high strength. The structures of the blend films were investigated by infrared spectrum and X-ray diffraction. The results indicated the occurrence of hydrogen bonds between hydroxyl groups of cellulose and amido groups of fibroin.