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利用 Hansch方法定量地研究了 2 0种磺酰脲和 16种嘧啶磺酰胺除草剂的结构与活性间关系。结果表明这两类化合物的构效关系是一致的 ,这意味着它们能作用于靶标的同一部位。影响化合物活性的主要因素是分子的电性 ,它们与受体作用时具有一个最佳电性值 (Σσ或 p Ka)。
Hansch method was used to quantitatively study the relationship between structure and activity of 20 sulfonylureas and 16 pyrimidine sulfonamide herbicides. The results show that the structure-activity relationship of these two classes of compounds is consistent, which means they can act on the same site of the target. The main factor that affects the activity of a compound is the electrical properties of the molecule, which have an optimal electrical value (Σσ or p Ka) when acting on the acceptor.