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A highly efficient catalytic system composed of a simple and commercially available chiral primary diamine(1R,2R)-cyclohexane-1,2-diamine(6) and trifluoroacetic acid(TFA) was employed for asymmetric Aldol reaction in i-PrOH at room temperature.A loading of 10%(molar fraction) catalyst 6 with TFA as a cocatalyst could catalyze the Aldol reactions of various ketones or aldehydes with a series of aromatic aldehydes,furnishing Aldol products in moderate to high yields(up to >99%) with enantioselectivities of up to >99% and diastereoselectivities of up to 99:1.
A highly efficient catalytic system composed of a simple and commercially available chiral primary diamine (1R, 2R) -cyclohexane-1,2-diamine (6) and trifluoroacetic acid (TFA) was employed for asymmetric Aldol reaction in i-PrOH at room temperature .A loading of 10% (molar fraction) catalyst 6 with TFA as a cocatalyst could catalyzed the Aldol reactions of various ketones or aldehydes with a series of aromatic aldehydes, furnishing Aldol products in moderate to high yields (up to> 99%) with enantioselectivities of up to> 99% and diastereoselectivities of up to 99: 1.