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慢性乙型肝炎(简称慢乙肝)的抗病毒治疗,是临床上一个重要的研究课题。目前用于抗病毒治疗的药物主要为干扰素和阿糖腺苷及其衍生物,亦有试用无环鸟苷及病毒唑者。兹复习近年来的文献资料并综述如下。干扰素(IFN) IFN是宿主有核细胞对病毒反应产生的一种蛋白质。通常有三种由不同细胞产生的IFN:(1)α-IFN:由B淋巴细胞和单核细胞所产生。一种称为人白细胞IFN(Huα-IFN)是由人血块黄层细胞产生;另一种称为人淋巴样母细胞IFN(Wellferon)是由人淋巴样母细胞产生,是至少有8种αS-IFN的混合物。(2)β-IFN:由成纤维细胞所产生。(3)γ-IFN(或称免疫IFN):
Chronic hepatitis B (referred to as chronic hepatitis B) antiviral therapy, is an important clinical research topic. At present, the drugs used for antiviral therapy are mainly interferon and vidarabine and its derivatives, as well as trials of acyclovir and ribavirin. We review the literature in recent years and summarized as follows. Interferon (IFN) IFN is a protein produced by a host’s nucleated cells in response to a virus. There are usually three types of IFN produced by different cells: (1) α-IFN: produced by B lymphocytes and monocytes. One known as human leukocyte IFN (Huα-IFN) is produced by human blood clot layer yellow cells; the other known as human lymphoid cells IFN (Wellferon) is produced by human lymphoid cells is at least eight αS-IFN mixture. (2) β-IFN: produced by fibroblasts. (3) γ-IFN (or immune IFN):