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目的:了解糖尿病患者、血糖调节受损者与血糖正常人群血清铜、锌和镁元素含量的差异,并探讨血糖变化与微量元素含量之间的关系,为中老年人健康诊断提供初步的依据。方法:随机选取大连市中老年人体检血清样本188例,根据血糖值将研究对象分为糖耐量正常组(NGT),血糖调节受损组(IGT),新诊糖尿病组(NDM)。利用火焰原子吸收光谱法(FAAS)分别测定其血清中铜、锌和镁的含量,并进行相关性分析。结果:NDM组血清锌含量显著低于NGT组(P<0.05),血清镁含量显著低于正常组(P<0.05)和IGT组(P<0.01),铜元素没有显著性差异。血清铜、锌和镁含量在NGT组和IGT组中,呈显著相关(P<0.01)。结论:血糖调节受损者和糖尿病患者体内存在铜、锌和镁元素代谢紊乱,对糖尿病的预防及治疗有着重要的意义。
OBJECTIVE: To investigate the differences of serum copper, zinc and magnesium contents in diabetic patients, impaired glucose regulation and normal blood glucose groups, and to explore the relationship between the changes of blood glucose and the content of trace elements, and to provide a preliminary basis for the health diagnosis of middle-aged and elderly people. Methods: A total of 188 serum samples from middle-aged and elderly people in Dalian were randomly selected and divided into normal glucose tolerance group (NGT), impaired glucose regulation (IGT) and new diabetes mellitus (NDM). The contents of copper, zinc and magnesium in serum were determined by flame atomic absorption spectrometry (FAAS), and the correlation analysis was carried out. Results: The levels of serum zinc in NDM group were significantly lower than those in NGT group (P <0.05). The content of serum magnesium in serum of NDM group was significantly lower than that of normal group (P <0.05) and IGT group (P <0.01). Serum copper, zinc and magnesium levels were significantly correlated between NGT group and IGT group (P <0.01). Conclusion: There is copper, zinc and magnesium metabolism disorder in the subjects with impaired glucose regulation and diabetes mellitus, which is of great significance for the prevention and treatment of diabetes mellitus.