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钩藤碱(Rhy)明显抑制AA,胶原及ADP诱导的大鼠血小板聚集。Rhy不影响血小利用外源性AA合成TXA_2,但抑制胶原诱导的TXA_2生成;在抗血小板聚集有效剂量时,对PGI_2的生成无影响。Rhy有显著降低血栓形成诱导剂ADP及胶原加肾上腺素静脉注射所致小鼠死亡率。
Rhy significantly inhibited AA, collagen and ADP-induced platelet aggregation in rats. Rhy did not affect the blood synthesis of exogenous AA TXA_2, but inhibited collagen-induced TXA_2 generation; effective dose of anti-platelet aggregation, PGI_2 generation had no effect. Rhy significantly reduced the mortality of mice induced by ADP and collagen plus adrenaline intravenously.