早在1885年,路易·巴斯德证明狂犬病毒能通过兔神经系统重复传代而减毒,并制备出有效的疫苗首次用于人体免疫,从而开创了人用狂犬病疫苗的发展史。人用狂犬病疫苗的发展经历了从传统的神经组织疫苗到现行的以组织培养疫苗为主的过程,并且正在应用现代生物技术不断改进和发展。? As early as 1885, Louis Pasteur proved that rabies virus can be attenuated by repeated passages in the rabbit’s nervous system and prepared for the first time an effective vaccine for human immunity, thus creating a history of human rabies vaccine. The development of rabies vaccine for human beings has gone through the process from the traditional nerve tissue vaccine to the current tissue culture vaccine and is undergoing continuous improvement and development using modern biotechnology. ?