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药理作用 ｍｉｚｏｌａｓｔｉｎｅ是一高选择性、高效的组胺Ｈ1受体拮抗剂,对啮齿动物的ＩＣ50为47ｎｍｏｌ·Ｌ-1。它对Ｈ1受体有高度特异性,但对5ＨＴ、去甲肾上腺素和毒蕈碱胆碱受体无作用。与其他7种Ｈ1受体拮抗剂相比较,ｍｉｚｏｌａｓｔｉｎｅ作用强度列第四位。ｍｉｚ
Pharmacological effects Mizolastine is a highly selective and potent histamine H1 receptor antagonist with IC50 of 47 nmol·L-1 for rodents. It is highly specific for H1 receptors but has no effect on 5HT, norepinephrine and muscarinic cholinergic receptors. Compared with the other seven H1-receptor antagonists, mizolastine ranked fourth. miz