青霉崇和头孢菌素类抗菌素具有高效低毒的特点,而头孢菌素比青霉素更为优越,其抗菌谱广,包括对耐青霉素的金黄色葡萄球菌有效,临床应用中,已日益显示出它的重要性。对半合成青霉素、头孢菌素的结构与活性关系的研究表明,在青霉素、头孢菌素的分子结构中,引入某些亲水性极性基团,往往可以扩大其抗菌谱或增强抗菌活性。 Penicillium and cephalosporin antibiotics with high efficiency and low toxicity characteristics, and cephalosporins than penicillin more superior antibacterial spectrum, including penicillin-resistant Staphylococcus aureus effective clinical application, has been increasingly shown It’s importance. Studies on the relationship between structure and activity of semicompound penicillins and cephalosporins have shown that the introduction of certain hydrophilic polar groups in the molecular structure of penicillins and cephalosporins can often broaden their antibacterial spectrum or enhance their antibacterial activity.