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目的探讨不同剂量阿司匹林治疗脑梗塞对患者血清高敏C-反应蛋白的影响。方法 80例脑梗塞确诊患者随机分为A组和B组,每组各40例,选择同期门诊健康体检者40例作为对照组。观察不同病情脑梗塞组入院前后hs-CRP表达水平,并与对照组hs-CRP水平进行比较,比较不同剂量阿司匹林治疗前后hs-CRP水平变化。结果脑梗塞患者入院时血清hs-CRP水平显著高于对照组(P<0.05),重型脑梗塞患者hs-CRP水平显著高于中型、轻型,中型hs-CRP水平显著高于轻型(P<0.05),两组治疗前hs-CRP水平差异无统计学意义,B组治疗后hs-CRP水平显著低于A组(P<0.05)。结论 hs-CRP水平与脑梗死发生、发展、预后密切相关,可作为诊断脑梗死及判断预后的重要指标。
Objective To investigate the effect of different doses of aspirin on serum high-sensitivity C-reactive protein in patients with cerebral infarction. Methods Eighty patients diagnosed with cerebral infarction were randomly divided into group A and group B, 40 cases in each group. 40 healthy subjects were selected as the control group. The expression of hs-CRP in different cerebral infarction patients before and after admission was observed and compared with that in control group. The hs-CRP levels before and after different doses of aspirin were compared. Results The serum levels of hs-CRP in patients with cerebral infarction were significantly higher than those in control group (P <0.05). The levels of hs-CRP in patients with severe cerebral infarction were significantly higher than those in patients with moderate cerebral infarction (P <0.05) ). There was no significant difference in hs-CRP levels between the two groups before treatment. The level of hs-CRP in group B was significantly lower than that in group A (P <0.05). Conclusion The level of hs-CRP is closely related to the occurrence, development and prognosis of cerebral infarction. It may be used as an important index in diagnosis of cerebral infarction and prognosis.