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前哨淋巴结活检(sentinel lymph node biopsy,SLNB)已成为乳腺癌手术治疗的重要组成部分,其方法包括染料法、放射性核素法以及两者联合。但国内无批准的放射性示踪剂,使其临床推广受限。近红外荧光法依靠近红外光激发吲哚菁绿产生荧光,利用荧光显像装置来显像淋巴系统,能实时、动态检测皮下淋巴管和淋巴结,使得切口定位明确,组织损伤小,并可避免以上方法的诸多缺点,但需术中关闭无影灯,使手术时间延长,以及淬火效应导致荧光亮度衰减、探测深度受限等问题。另外,与染料法联合应用以提高前哨淋巴结检出率等问题,尚需l缶床试验进一步验证。
Sentinel lymph node biopsy (SLNB) has become an important part of the surgical treatment of breast cancer, and its methods include dye method, radionuclide method, and a combination of the two. However, no domestic approval of radioactive tracers, to make its clinical promotion limited. Near infrared fluorescence method relies on near infrared light to stimulate indocyanine green fluorescence, the use of fluorescence imaging device to visualize the lymphatic system, real-time, dynamic detection of subcutaneous lymphatic vessels and lymph nodes, making the incision clear positioning, tissue damage and avoid Many shortcomings of the above methods, but need to be closed intraoperative shadowless lamp, the operation time is extended, as well as the quenching effect causes fluorescent brightness decay, limited exploration depth and other issues. In addition, combined with the dye method to improve the detection rate of sentinel lymph nodes and other issues, still need l 缶 bed test for further verification.