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目的:探讨益气化痰解毒中药治疗脂肪肝药效学机制。方法:采用高脂饮食加白酒灌胃建立大鼠脂肪性肝炎模型,以东宝肝泰作对照,观察益气化痰解毒中药对脂肪肝大鼠肝组织核因子-κB(NF-κB)活性变化、肿瘤坏死因子(TNFa)、转化生长因子β1(TGF-β1)的影响。结果:大鼠第10周出现严重的内毒素血症;模型组大鼠比正常组NF-κB、TNFa、TGF-β1水平均明显升高(P<0.01);中药能抑制NF-κB活化,降低TNFa、TGF-β1的含量,均明显优于东宝肝泰(P<0.05)。结论:益气化痰解毒中药具有较强抗脂肪性肝炎效应,其作用机制与其抑制NF-κB过度活化有关。
Objective: To investigate the pharmacodynamic mechanism of Yiqi Huatan detoxification traditional Chinese medicine in treating fatty liver. Methods: A rat model of steatohepatitis was induced by high-fat diet plus liquor. The rats were treated with Dongbaogantai for observing the activity of NF-κB in hepatic tissue of rats with fatty liver Changes, tumor necrosis factor (TNFa), transforming growth factor β1 (TGF-β1). Results: Serum endotoxemia occurred in the 10th week in rats. The levels of NF-κB, TNFa and TGF-β1 in model group were significantly higher than those in normal group (P <0.01) Reduce TNFa, TGF-β1 content, were significantly better than Dongbao liver Thai (P <0.05). Conclusion: Yiqi Huatan detoxification Chinese medicine has a strong anti-steatohepatitis effect, its mechanism of action and its inhibition of NF-κB over-activation.