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目的:观察柴胡疏肝散对原发性抑郁症患者脑干听觉诱发电位(BAEP)和视觉诱发电位(VEP)的影响。方法:将100例原发性抑郁症患者随机分为中药组、西药组,分别给予中药柴胡疏肝散和盐酸帕罗西汀治疗,采用脑诱发电位仪,记录治疗前后BAEP和VEP。结果:两组经治疗后,BAEP的I、V波治疗前后无明显改变(P>0.05),Ⅲ波潜伏期较治疗前明显缩短(P<0.05),VEP各波潜伏期均显著缩短(P<0.05);治疗后两组BAEP、VEP相比无统计学差异(P>0.05)。结论:柴胡疏肝散可缩短原发性抑郁症患者BAEP和VEP的潜伏期,减轻患者临床症状,具有应用价值。
Objective: To observe the effect of Chaihu Shugan San on brainstem auditory evoked potential (BAEP) and visual evoked potentials (VEP) in patients with primary depression. Methods: One hundred patients with primary depression were randomly divided into two groups: traditional Chinese medicine group and western medicine group. The patients were treated with Chaihu Shugan San and paroxetine hydrochloride respectively. The brain evoked potentials were used to record the changes of BAEP and VEP before and after treatment. Results: After treatment, there was no significant change in I and V waves of BAEP before and after treatment (P> 0.05). The latency of Ⅲ wave was significantly shorter than that before treatment (P <0.05) ); There was no significant difference between the two groups after treatment BAEP, VEP (P> 0.05). Conclusion: Chaihu Shugan Powder can shorten the latent period of BAEP and VEP in patients with primary depression and reduce the clinical symptoms of patients with depression.