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目的评价联合检测Survivin和癌胚抗原(CEA)对肺癌诊断价值。方法检测77例肺癌患者和72例良性胸腔积液患者胸腔积液中Survivin和CEA水平,应用ROC曲线评价诊断效能。结果 Survivin和CEA在最优截断点的灵敏度分别为80.5%和71.4%,特异度分别为86.1%和84.7%;平行试验灵敏度和特异度为94.4%和72.9%;系列试验灵敏度和特异度为57.5%和97.8%。结论联合检测胸腔积液Survivin和CEA对肺癌诊断价值优于单独检测。
Objective To evaluate the diagnostic value of combined detection of Survivin and carcinoembryonic antigen (CEA) in lung cancer. Methods The levels of Survivin and CEA in pleural effusion of 77 patients with lung cancer and 72 patients with benign pleural effusion were measured. The diagnostic efficiency was evaluated by ROC curve. Results The sensitivity and specificity of Survivin and CEA were 80.5% and 71.4%, respectively, with specificity of 86.1% and 84.7%, respectively. The sensitivity and specificity of parallel tests were 94.4% and 72.9%, respectively. The sensitivity and specificity of series of tests were 57.5 % And 97.8%. Conclusions The combined detection of Survivin and CEA in pleural effusion is better than single detection in diagnosis of lung cancer.