美国俄亥俄医学院以约翰·勒普(John Rapp)为首的研究小组,在食用高盐食饵而产生高血压的老鼠身上,已经鉴定出某种与高血压有关的基因,这种基因至少是导致高血压的因素之一。基因位点命名为 Hyp-1(即高血压之意),它专为一种酶而编码,这种酶导致18-羟基-脱氧皮质甾体的合成。此甾体是一种激素,与已知能诱发人体血压增高的甾族化合物相似。基因位点是在 S 系老鼠中鉴定的。此种老鼠连续八周喂给高盐食饵时会产生异常高血压(200～240 A team led by John Rapp at the Ohio School of Medicine in the Hypertension rat, who consumed high-salt prey, has identified a gene associated with high blood pressure that causes at least high One of the factors of blood pressure. The gene site, named Hyp-1 (meaning hypertension), is coded for an enzyme that leads to the synthesis of 18-hydroxy-deoxycorticosteroids. This steroid is a hormone similar to steroids known to induce elevated blood pressure in the body. Gene loci were identified in S-line mice. The rats fed high-salt bait for eight weeks in a row had abnormal high blood pressure (200-240