论文部分内容阅读
通过主胰管逆行注入不同剂量的胆汁和胰蛋白酶混合液，在２２只猫诱发了程度不同的急性胰腺炎。组织病理学表明：Ａ组动物主胰管注入０．８ｍｌ／ｋｇ混合液，诱发的胰腺炎较轻，病理改变以间质水肿为主；Ｂ组动物注射１．０ｍｌ／ｋｇ混合液，胰腺病变为广泛坏死；Ｃ组动物注射１．２ｍｌ／ｋｇ混合液，胰腺广泛坏死合并肺、肝损害。所有实验动物腹腔液淀粉酶均明显升高，升高幅度与胰腺病变程度呈正比，与实验动物的生存时间呈反比。Ａ组动物腹腔液淀粉酶为４８９０Ｕ／Ｌ，其生存时间在７ｄ以上；胰腺坏死严重的Ｂ组动物，腹腔液淀粉酶为１３９５２Ｕ／Ｌ，生存时间５０．４ｈ；Ｃ组动物腹腔液淀粉酶２３８１０Ｕ／Ｌ，生存时间１０．４ｈ。实验结果表明：腹腔液淀粉酶测定对估价急性胰腺炎病变程度及预后有显著意义，可做为评定急性胰腺炎病变程度及估价预后的重要指标。
A retrograde injection of different doses of bile and trypsin mixture through the main pancreatic duct induced a degree of acute pancreatitis in 22 cats. Histopathology showed that: Group A animals injected into the main pancreatic duct 0.8ml / kg mixture, less induced pancreatitis, pathological changes of interstitial edema; Group B animals injected 1.0ml / kg mixture of pancreatic lesions For a wide range of necrosis; Group C animals injected with 1.2ml / kg mixture of extensive necrosis of the pancreas with lung and liver damage. All experimental animals, peritoneal fluid amylase were significantly increased, the magnitude of the increase was proportional to the degree of pancreatic lesions, and experimental animals were inversely proportional to the survival time. A group of animal peritoneal fluid amylase 4890U / L, the survival time of more than 7d; pancreatic necrosis severe group B animals, peritoneal amylase 13952U / L, the survival time of 50.4h; C group of animal peritoneal amylase 23810U / L, survival time 10.4h. The experimental results show that the peritoneal fluid amylase assay has a significant value in the evaluation of the severity and prognosis of acute pancreatitis and can be used as an important index to assess the severity of acute pancreatitis and evaluate the prognosis.