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用细胞生长曲线测定法及软琼脂集落形成分析法研究了ＨＨ０７Ａ对几种肿瘤及正常细胞生长的影响。结果表明，１．５ｕｇ·ｍｌ－１及３μｇ·ｍｌ－１ＨＨ０７Ａ能分别明显抑制Ｌ１２１０和ＨＬ－６０细胞的生长。３种肿瘤细胞对ＨＨ０７Ａ的敏感性依次为Ｌ１２１０＞ＫＢ＞ＨＬ－６０，而正常小鼠粒系祖细胞ＧＭ－ＣＰＣ对药物的敏感性则低于前三者，且ＨＨ０７Ａ３．５μｇ·ｍｌ－１对ＨＬ－６０细胞无分化诱导作用。ＨＨ０７Ａ对腹水型Ｌ１２１０白血病小鼠、Ｓ１８０小鼠均有较明显的治疗作用，使Ｌ１２１０荷瘤小鼠、Ｓ１８０荷瘤小鼠存活时间延长。也能抑制Ｓ１８０实体瘤的生长。
The effects of HH07A on the growth of several tumors and normal cells were studied by cell growth curve assay and soft agar colony formation assay. The results showed that 1.5ug · ml-1 and 3μg · ml-1HH07A could significantly inhibit the growth of L1210 and HL-60 cells respectively. The sensitivity of three kinds of tumor cells to HH07A was L1210> KB> HL-60, while the sensitivity to GM-CPC of normal mouse myeloid progenitor cells was lower than the former three, and HH07A3.5μg · ml-1 Induction of differentiation of HL-60 cells. HH07A on ascites L1210 leukemia mice, S180 mice have a more significant therapeutic effect, so L1210 tumor-bearing mice, S180 tumor-bearing mice prolonged survival. It also inhibits the growth of S180 solid tumors.