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目的 探讨脑出血患者血清与局部血肿内自由基的关系。方法 对 37例危重型脑出血患者进行CT引导下血肿抽吸引流 ,同时分别测定血清及血肿内脂质过氧化物丙二醛 (MDA)含量及过氧化物歧化酶 (SOD)总活力 ,然后进行统计学分析。结果 血肿内MDA及SOD水平明显高于血清 ,有极显著差异(P <0 0 1 )。结论 脑血肿内自由基水平可作为临床估计预后的一种指标。
Objective To investigate the relationship between serum and local free radicals in patients with intracerebral hemorrhage. Methods Thirty-seven patients with critical cerebral hemorrhage underwent CT-guided hematoma aspiration and drainage. Serum and hematoma contents of serum lipid and malondialdehyde (MDA) and total superoxide dismutase (SOD) were measured. Statistical analysis. Results The levels of MDA and SOD in the hematoma were significantly higher than those in the serum (P <0.01). Conclusion The level of free radicals in cerebral hematoma can be used as an index of clinical prognosis.