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目的：探讨干性型老年黄斑变性（ａｇｅ－ｒｅｌａｔｅｄｍａｃｕｌａｒｄｅｇｅｎｅｒａｔｉｏｎ，ＡＭＤ）的病变发展特征并寻找监测ＡＭＤ病情进展的较敏感指标。方法：用眼底彩色照相和眼底荧光血管造影（ＦＦＡ）、明视视网膜电图（ＥＲＧ）、ＦＭ１００－ｈｕｅ色彩试验及视力检查，对６０例（１１１眼）５０～８０岁、视力≤１．０的干性型ＡＭＤ患者进行３～７４个月（平均３０．２个月）的随访观察。结果：本组６８眼经ＦＦＡ检查、平均２５．６个月随访，其中２５％的患眼病灶损害有快慢不一的发展。全部１１１眼视力在平均３０．２个月随访中有１８％患眼的视力下降２行以下，且与病灶进展相符，ＦＭ１００－ｈｕｅ色彩试验的被随访者中，随访２年以后，其总错误分明显的增加（Ｐ＜０．０１）。６３眼的明视ＥＲＧ在随访过程中无明显变化。结论：大部分干性ＡＭＤ患眼的病灶损害和视力可以在较长时间内维持稳定。ＦＭ１００－ｈｕｅ的总错误分可能为监测ＡＭＤ病情进展的较敏感指标。
Objective: To investigate the pathological features of age-related macular degeneration (AMD) and to find more sensitive indicators to monitor the progression of AMD. Methods: Sixty cases (111 eyes) aged 50 ~ 80 years with visual acuity of ≤1.0 were examined by fundus color photography and fundus fluorescein angiography (FFA), ERG, FM100-hue colorimetry and visual acuity test Of patients with dry AMD were followed up for 3 to 74 months (average 30.2 months). Results: The group of 68 eyes by FFA examination, an average of 25.6 months follow-up, of which 25% of the affected eye lesions with different speed of development. All 111 eyes had visual acuity of less than 2 lines in 18% of eyes with an average of 30.2 months of follow-up, consistent with the progression of the lesion. Of the respondents who were followed up for 2 years in the FM100-hue color test, the total error Markedly increased (P <0.01). There was no significant change in 63 eyes of ERG during follow-up. CONCLUSIONS: Lesions and visual acuity in most patients with dry AMD may be stable over longer periods of time. The total error score of FM100-hue may be a more sensitive indicator for monitoring the progression of AMD.