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目的探究曲美他嗪治疗急性冠脉综合征心功能不全的临床疗效。方法选取医院收治的91例急性冠脉综合征心功能不全患者作为研究对象,随机分为2组。对照组患者45例,给予常规药物进行治疗,观察组患者46例,在对照组治疗基础上,加用曲美他嗪进行治疗,比较2组的治疗有效率及6 min步行距离。结果观察组患者治疗有效率为95.65%,高于对照组的82.22%(P<0.05);治疗前观察组患者6 min步行距离为(341.25±65.26)m,治疗后6 min步行距离为(462.36±64.37)m;治疗前对照组6 min步行距离为(332.54±56.37)m,治疗后6 min步行距离为(401.25±66.37)m。治疗前2组患者6 min步行距离比较差异无统计学意义(P>0.05);治疗后,观察组6min步行距离优于对照组(P<0.01)。结论对急性冠脉综合征心功能不全患者在常规治疗基础上采用曲美他嗪治疗效果较好,可提高患者6 min步行距离,改善临床症状,临床应用价值较高。
Objective To investigate the clinical efficacy of trimetazidine in the treatment of cardiac insufficiency in patients with acute coronary syndrome. Methods Ninety-one patients with acute coronary syndromes admitted to the hospital were enrolled as study subjects and randomly divided into two groups. Control group of 45 patients, given conventional drugs for treatment, the observation group of 46 patients on the basis of the control group, plus trimetazidine treatment, the two groups were compared the efficiency and 6 min walking distance. Results The effective rate of observation group was 95.65%, higher than that of control group (82.22%) (P <0.05). Before treatment, the walking distance of patients in observation group was (341.25 ± 65.26) m and the walking distance at 6min after treatment was (462.36) ± 64.37) m. Before the treatment, the walking distance of the control group for 6 min was (332.54 ± 56.37) m and the walking distance was (401.25 ± 66.37) m after 6 min. There was no significant difference in walking distance between the two groups before 6 minutes of treatment (P> 0.05). After 6 minutes of walking, the walking distance of observation group was better than that of control group (P <0.01). Conclusion The treatment of patients with acute coronary syndromes with cardiac insufficiency based on conventional therapy is better than trimetazidine, which can improve the patient’s 6-minute walking distance, improve clinical symptoms and have higher clinical value.