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缺氧诱导因子-1α(HIF-1α)是与氧气内环境有关的关键转录因子,其调控缺氧引起的多种细胞适应性反应,如血管新生、新陈代谢以及细胞凋亡等。肥胖时,脂肪组织功能紊乱与IR成对出现,形成局部缺氧,出现血管新生障碍。相似的,T2DM可引起组织局部缺氧及HIF-1α的产生受到抑制,血管新生因子下调,最终引起多种血管并发症。同时,异常表达的微小RNA(microRNAs)对HIF-1α的表达及其功能有着极为重要的作用。HIF-1α在血管新生、伤口愈合等方面起重要作用。HIF-1α可结合缺氧反应元件,调节VEGF的表达,进而促进血管新生。本文就HIF-1α及其对糖尿病血管新生的影响做一综述。
Hypoxia-inducible factor-1α (HIF-1α) is a key transcriptional factor related to oxygen homeostasis, which regulates a variety of cellular adaptive responses induced by hypoxia, such as angiogenesis, metabolism and apoptosis. Obesity, adipose tissue dysfunction and IR appear in pairs, the formation of local hypoxia, angiogenesis disorders. Similarly, T2DM can cause local hypoxia and inhibition of HIF-1α production, down-regulation of angiogenic factors, and eventually lead to a variety of vascular complications. Meanwhile, abnormally expressed microRNAs play an extremely important role in the expression and function of HIF-1α. HIF-1α plays an important role in angiogenesis and wound healing. HIF-1α can bind to hypoxia response elements, regulate the expression of VEGF, thereby promoting angiogenesis. This article reviews HIF-1α and its effects on angiogenesis in diabetes.