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在患急性疟疾时,可出现许多种病变。例如:骨髓造血干细胞分裂减慢、肝脏受损、血糖水平发生改变、肾上腺功能不全、消耗性凝血病、肾功能衰竭等。以上这些病变,并不能轻易地归咎于循环红细胞内的疟原虫。作者给感染文氏疟原虫彼氏亚种(P.vinckei petteri)的小鼠静脉内注射20μg内毒素,2小时后取血检验。结果在血中发现了巨噬细胞衍化的介质。其中包括:肿瘤坏死因子(TNF)、糖皮质激素拮抗因子(GAF)、淋巴细胞活化因子(LAF),I型干扰素(IFtype I)以及淋巴细胞释放的移动抑制因子(MIF)。
There are many types of disease that can occur when suffering from acute malaria. For example: bone marrow hematopoietic stem cell division slows, liver damage, blood glucose levels change, adrenal insufficiency, consumptive coagulopathy, renal failure and so on. These lesions can not easily be attributed to circulating red blood cells within the parasite. The authors injected mice infected with P. vulgaris petteri intravenously with 20 μg of endotoxin and a blood test two hours later. As a result, macrophage-derived mediators were found in the blood. These include: tumor necrosis factor (TNF), glucocorticoid antagonist (GAF), lymphocyte activation factor (LAF), type I interferon (IFtype I), and lymphocyte mobilization inhibitor (MIF).