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目的:验证帕罗西汀对早泄的治疗效果。方法:将符合纳入标准的80例早泄患者随机分为试验组和对照组,每组40例。所有患者进入为期4周的基线水平观察期,记录治疗前的阴道内射精潜伏时间(IELT)和性交满意度分值。试验组每天口服帕罗西汀20 mg,对照组口服安慰剂。治疗30 d后记录每个患者治疗后的IELT值和性交满意度分值。结果:试验组治疗后平均IELT与治疗前比较明显延长(5.75±1.24 min vs 0.89±0.21min,P<0.01),性交满意度与治疗前比较明显提高(6.4±1.2分vs 2.7±0.9分,P<0.01)。对照组治疗后平均IELT和性交满意度与治疗前比较均无显著性差异(1.06±0.28 min vs 0.97±0.18 min,3.6±1.3分vs 3.1±1.1分,P>0.05)。结论:早泄患者每天口服帕罗西汀20 mg,30 d后IELT和性交满意度均有明显改善。
Objective: To verify the therapeutic effect of paroxetine on premature ejaculation. Methods: Eighty patients with premature ejaculation who met the inclusion criteria were randomly divided into experimental group and control group, 40 cases in each group. All patients entered a 4-week baseline observation period and recorded IOVT and sexual satisfaction scores before treatment. Paroxetine 20 mg orally daily in the test group and placebo in the control group. After treatment for 30 days, IELT scores and sexual satisfaction scores of each patient after treatment were recorded. Results: After treatment, the average IELT in experimental group was significantly longer than that before treatment (5.75 ± 1.24 min vs 0.89 ± 0.21min, P <0.01), and sexual satisfaction was significantly improved after treatment (6.4 ± 1.2 vs 2.7 ± 0.9, P <0.01). There was no significant difference in mean IELT and sexual satisfaction between the two groups after treatment (1.06 ± 0.28 min vs. 0.97 ± 0.18 min, 3.6 ± 1.3 vs 3.1 ± 1.1, P> 0.05). Conclusions: Patients with premature ejaculation orally daily oral paroxetine 20 mg, 30 d after IELT and sexual satisfaction were significantly improved.