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采取高效液相色谱法，测定唾液氨茶碱浓度，研究了藏、汉族健康志愿者氨茶碱半衰期（Ｔ１／２）和消除速率常数（Ｋ）的差异；以及高原区藏族人氨茶碱的Ｔ１／２和Ｋ。１４例藏族人氨茶碱Ｔ１／２为８．１２±２．１０ｈ，Ｋ为０．０８９８±０．０３１（ｈ￣－１）；１３例汉族人氨茶碱Ｔ１／２为８．７１±２．４４ｈ，Ｋ为０．０８５８±０．０２７７（ｈ￣－１）。９例高原区藏族人氨茶碱Ｔ１／２为９．５０±３．０９（ｈ）￣－１，Ｋ为０．０８２９±０．０３８６（ｈ￣－１）。实验结果表明，藏、汉两民族氨茶碱Ｔ１／２及Ｋ无明显差异，居住高原地区不影响氨茶碱代谢。
To determine the aminophylline half-life (T1 / 2) and elimination rate constant (K) in Tibetans and Han nationality healthy volunteers by high performance liquid chromatography (HPLC) T1 / 2 and K. The aminophylline T1 / 2 in 14 Tibetans was 8.12 ± 2.10 hours and K was 0.0898 ± 0.031 (h ~ -1). The aminophylline T1 / 2 in 13 Han people was 8.71 ± 2.44h, K is 0.0858 ± 0.0277 (h ~ -1). Nine cases of Tibetan aminophylline T1 / 2 in the plateau were 9.50 ± 3.09 (h) ~ -1, K was 0.0829 ± 0.0386 (h ~ -1). The experimental results show that Tibet and Han both aminophylline T1 / 2 and K no significant difference in the living plateau does not affect the metabolism of aminophylline.