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目的 :探讨bcl- 2蛋白在人膀胱癌中表达的临床意义。方法 :取 5 7例经病理证实的膀胱肿瘤标本 ,应用免疫组化技术检测石蜡包埋在组织切片中bcl- 2的表达。结果 :正常膀胱粘膜组织bcl- 2蛋白呈阴性。膀胱移行细胞癌Ⅰ级 15例 ,阳性率13 .3 % ;Ⅱ级 16例 ,阳性率 6 .2 % ;Ⅲ级 18例 ,阳性率 5 0 .0 %。膀胱横纹肌肉瘤阳性 1例 ,葡萄状肉瘤阳性 1例 ,内胚窦瘤阳性1例。结论 :凋亡抑制基因bcl- 2蛋白在人膀胱不同细胞类型的肿瘤中有表达 ,在移行细胞中的表达与临床病理分级有一定的相关关系
Objective: To investigate the clinical significance of bcl-2 protein expression in human bladder cancer. Methods: Fifty-seven specimens of bladder tumor confirmed by pathology were collected. The expression of bcl-2 in paraffin-embedded tissue sections was detected by immunohistochemistry. Results: The normal bladder mucosa bcl-2 protein was negative. Grade I bladder transitional cell carcinoma in 15 cases, the positive rate was 13.3%; grade Ⅱ 16 cases, the positive rate of 6.2%; Ⅲ grade 18 cases, the positive rate of 50.0%. Bladder rhabdomyosarcoma was positive in 1 case, grape-like sarcoma was positive in 1 case, endodermal sinus tumor was positive in 1 case. CONCLUSION: The apoptosis-inhibiting gene bcl-2 protein is expressed in different types of human bladder cancer cells. The expression of bcl-2 protein in transitional cell is related to the clinicopathological grade