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目的 研究小儿术前应用氯胺酮的最佳途径和剂量。方法 不同剂量口服给药及肌肉给药进行临床效果对照比较。结果 小儿术前口服１０ ｍｇ·ｋｇ － １ 氯胺酮后，能入睡，与父母分开时无反应，能接受静脉穿刺或硬膜外穿刺，减少术中其它麻醉药用量，且唾液分泌、喉痉挛、肌肉强直等副反应明显减少。结论 口服氯胺酮１０ ｍｇ·ｋｇ － １ 是小儿术前较好的给药方法。
Objective To study the best way and dose of ketamine before operation in children. Methods Different doses of oral administration and muscle administration compared the clinical results. Results After preoperative oral administration of 10 mg · kg - 1 ketamine, the mice could fall asleep and did not respond when separated from their parents. They were able to receive venipuncture or epidural puncture and reduce the amount of other anesthetics used in the operation. Salivary secretion, laryngospasm, Muscle rigidity and other side effects significantly reduced. Conclusion Oral ketamine 10 mg · kg - 1 is a good method for preoperative administration in children.