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目的 探讨氨溴索 (沭舒坦 )治疗小儿细菌性肺炎的临床疗效及不良反应。方法 14 2例细菌性肺炎患儿随机分为两组 :( 1)治疗组 :70例 ;( 2 )对照组 :72例。治疗组采用 0 .9%生理盐水 2 0～ 10 0ml+头孢拉定 4 0mg/(kg·次 ) ,静脉点滴 ,在滴注 5min后从静脉针头处静注生理盐水 5ml+氨溴索 ( <5岁 7.5mg、>5岁 15mg) ,静注时间 >5min ;对照组除不用氨溴索外 ,其他同治疗组。两组疗程均为 7～ 14d。结果 总有效率 :治疗组为 87.14 %( 6 1/70 ) ,对照组为 6 6 .6 7% ( 4 8/72 ) ,两组相比较 ,有显著性差异 (P <0 .0 5 )。痊愈率 :治疗组为 71.4 3% ( 5 0 /70 ) ,对照组为 5 6 .94 % ( 4 1/72 ) ,两组相比较 ,有显著性差异 (P <0 .0 5 )。体温恢复正常的时间 :治疗组为 ( 2 .2± 0 .5 8)d ,对照组为 ( 3.16± 0 .32 )d ,两组相比较 ,有显著性差异 (P <0 .0 5 ) ;白细胞恢复正常的时间 :治疗组为 ( 4 .8± 0 .82 )d ,对照组为 ( 6 .18± 1.0 2 )d ,两组相比较 ,有显著性差异 (P <0 .0 5 )。结论 氨溴索不仅有祛痰 ,止咳作用 ,且副作用小 ,还能增加抗生素在肺组织中的浓度 ,提高疗效
Objective To investigate the clinical efficacy and adverse reactions of ambroxol in children with bacterial pneumonia. Methods 14 2 children with bacterial pneumonia were randomly divided into two groups: (1) treatment group: 70 cases; (2) control group: 72 cases. The treatment group received 0. 9% normal saline 20 ~ 100ml + cefradine 40mg / (kg · times) intravenously, 5ml intravenous injection of saline (Ambroxol 5mg ,> 5 years old 15mg), intravenous injection time> 5min; control group except ambroxol, other with the treatment group. The two courses of treatment were 7 ~ 14d. Results The total effective rate was 87.14% (6 1/70) in the treatment group and 66.7% (48/72) in the control group, with significant difference between the two groups (P <0.05) . The cure rate was 71.4 3% (50/70) in the treatment group and 56.9% (4 1/72) in the control group. There was significant difference between the two groups (P <0.05). Body temperature returned to normal time: the treatment group was (2.2 ± 0.58) d, the control group was (3.16 ± 0.32) d, compared with the two groups, there was a significant difference (P <0.05) ; The normal time of leukocyte recovery was (4.88 ± 0.82) d in the treatment group and (6.18 ± 1.02) days in the control group, there was a significant difference between the two groups (P <0.05) ). Conclusion Ambroxol not only expectorant, cough, and side effects, but also increase the concentration of antibiotics in the lung tissue and improve the efficacy