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[目的]根据四川盐亭和河北磁县肿瘤登记处数据,比较1988～2007年中国两个不同地域食管癌高发区贲门癌发病趋势的变化。[方法]截取1988～2007年发病数据库ICD编码C16.0,组织学诊断比例76.4%～78.8%。贲门癌的发病采用y=α+βx+ε线性模型,计算年度变化百分比(APC)。[结果]四川盐亭1988年贲门癌中标率为11.04/10万,2007年17.66/10万;河北磁县则分别为7.62/10万和37.41/10万。四川盐亭贲门癌发病呈明显上升,男女合计贲门癌发病APC为5.89%,其中男性2.87%,女性2.84%,有统计学差异;河北磁县贲门癌发病的APC分别为7.66%、8.13%和6.46%(P=0.000)。[结论]中国两个不同地域食管癌高发区人群20年贲门癌发病均呈现明显的增长趋势,发病显著增高的原因与ICD编码规则和内镜的临床广泛应用关系密切。
[Objective] To compare the changes of incidence of cardia cancer in two high incidence areas of esophageal cancer from 1988 to 2007 in Sichuan Yanting and Hebei Cixian Cancer Registry. [Method] Intercepted ICD code C16.0 of incidence database from 1988 to 2007, the proportion of histological diagnosis was 76.4% -78.8%. Cardiac cancer incidence using y = α + βx + ε linear model to calculate the annual percentage change (APC). [Results] The success rate of cardia cancer in Yanting, Sichuan was 11.04 / 100 000 in 1988 and 17.66 / 100 000 in 2007, while that of Cixian in Hebei was 7.62 / 100 000 and 37.41 / 100 000 respectively. The incidence of cardia cancer in Yanting, Sichuan Province was significantly increased. The APC incidence rate of cardia cancer was 5.89% in men and 2.87% in male and 2.84% in female, with APC of 7.66%, 8.13% and 6.46% (P = 0.000). [Conclusion] The incidence of cardia cancer in 20 high-incidence areas of esophageal cancer in two different regions of China showed a significant trend of increase. The reason for the significantly increased incidence was closely related to the widespread use of ICD coding rules and endoscopy.