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目的探讨血清肌钙蛋白评价新生儿缺氧缺血性脑病时心肌损伤的应用价值。方法检测入院时及治疗7d后,重度HIE40例,轻度HIE45例正常新生儿40例的血清CTn-I的心肌酶水平。结果HIE时CK,CK-MB及CTNI水平明显增高。3组间比较差异有统计学意义。AST,LDH增高不明显无明显差异。CTNI的敏感度和特异度高于CK,CK-MB。结论CTn-I和CK-MB对HIE心肌损害均有诊断价值,CTn-I具有更高的特异性和灵敏度。
Objective To investigate the value of serum troponin in the evaluation of myocardial injury in neonates with hypoxic-ischemic encephalopathy. Methods Serum CTn-I levels were measured at admission and after 7 days of treatment in 40 severe HIE patients and 40 mild HIE neonates. Results HIE CK, CK-MB and CTNI levels were significantly higher. The difference between the three groups was statistically significant. AST, LDH increased no significant no significant difference. The sensitivity and specificity of CTNI are higher than those of CK and CK-MB. Conclusion CTn-I and CK-MB have diagnostic value for HIE myocardial injury, CTn-I has higher specificity and sensitivity.