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败血症是一个复杂的获得性代谢疾病.在感染时高分解代谢状态下,内源性脂肪的分解和动员增加,周围组织对脂肪的依赖性增加,高糖负荷下仍有持续性的净脂氧化.败血症患者的脂肪氧化能力与病情发展的不同阶段有关.感染时的多不饱和脂肪酸模式的异常及临床意义已引起人们关注.营养支持时,脂肪乳剂对免疫功能和内脏功能的影响与静脉乳剂的成份、剂量等有关.同时静脉输入脂肪和葡萄糖,可使二者的净能量生成增加.本文还探讨了败血症时影响脂肪代谢的原因.
Sepsis is a complex acquired metabolic disease, which is characterized by high levels of catabolism of endogenous lipids and increased mobilization of peripheral lipids, an increased dependence on fat in surrounding tissues, and sustained net lipid oxidation under high glucose load The ability of lipoxygenation in patients with sepsis is related to different stages of the disease progression.The abnormality and clinical significance of polyunsaturated fatty acid pattern during infection have aroused people’s attention.When nutritional support is given, the effect of fat emulsion on immune function and visceral function is similar to that of intravenous emulsion Composition, dose, etc .. At the same time, intravenous infusion of fat and glucose, can both increase the net energy generation.This article also discusses the causes of sepsis affect fat metabolism.