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NF-κB is a transcription factor of eukaryote,whose family comprises five members in mammals and three indrosophila.Transcription factors of the NF-κB family are activated in response to signals that lead to cellgrowth,differentiation,apoptosis and other events.NF-κB takes part in expression of numerous cytokines andadhesion molecules which are critical elements involved in the regulation of immune responses.In this review,we focus on our current understanding of NF-κB signal pathway and its role in the innate and adaptiveimmune responses in which these transcription factors have a key regulatory function.Furthermore we reviewwhat is currently known about their effects associated with apoptosis.Cellular & Molecular Immunology.2004;1(5):343-350.
Its family includes five members in mammals and three indrosophila. Transcription factors of the NF-κB family are activated in response to signals to lead that to cell growth, differentiation, apoptosis and other events. NF-κB takes part in expression of numerous cytokines andadhesion molecules which are critical elements involved in the regulation of immune responses. In this review, we focus on our current understanding of NF-κB signaling pathway and its role in the innate and adaptiveimmune responses in which these transcriptions Factors have a key regulatory function. More than that review is currently known about their effects associated with apoptosis. Cellular & Molecular Immunology. 2004; 1 (5): 343-350.