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The intragastric changes especially the changes of nitrite levelafter the cimetidine treatment with or without concomitant adminis-tration of vitamin C were studied in 34 patients with peptic ulcer.The pH value,nitrite level,and bacterial count of the gastric juiceafter cimetidine treatment were significantly higher than those priorto the treatment(P<0.01).If vitamin C was given simultaneouslywith cimetidine,then the nitrite level would not be elevated afterthe treatment(P>0.05).Besides,the reduction of BAO,PAO,andMAO was not influenced by vitamin C intake.It is believed thatvitamin C can reduce the nitrite concentration elevated by cimetidinetreatment,but it will not affect the acid-inhibitory function ofcimetidine.This fact is of importance for the safe application ofcimetidine.
The intragastric changes especially the changes of nitrite levelafter the cimetidine treatment with or without concomitant adminis-tration of vitamin C were studied in 34 patients with peptic ulcer. The pH value, nitrite level, and bacterial count of the gastric juice after cimetidine treatment were significantly higher (P <0.01) .If vitamin C was given simultaneouslywith cimetidine, then the nitrite level would not be elevated afterthe treatment (P> 0.05) .Besides, the reduction of BAO, PAO, andMAO was not influenced by vitamin C intake. It is believed that vitamin C can reduce the nitrite concentration elevated by cimetidinetreatment, but it will not affect the acid-inhibitory function of cimetidine. This fact is of importance for the safe application of cimetidine.