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【目的】探讨P-选择素(sP-selectin)和白细胞介素18(IL-18)在乙肝肝硬化及不同分期中的变化规律及其与肝功能受损的关系。【方法】78例乙肝后肝硬化患者,采用ELISA法测定血清sP-selectinI、L-18水平及肝功能。【结果】肝硬化患者血清sP-selectin、IL-18水平明显比正常对照组增加;血清sP-selectinI、L-18水平与肝功能的关系呈明显相关性。【结论】测定二者的水平变化可用于评估乙肝肝硬化患者肝功能状况及疾病的严重程度,对判断乙肝肝硬化患者的预后也具有一定的价值。
【Objective】 To investigate the changes of s-selectin and interleukin-18 (IL-18) in cirrhosis and staging of hepatitis B and their relationship with impaired liver function. 【Methods】 Seventy-eight patients with posthepatitic cirrhosis were tested for serum sP-selectin I, L-18 levels and liver function by ELISA. 【Results】 Serum levels of sP-selectin and IL-18 in patients with cirrhosis were significantly higher than those in normal controls. Serum sP-selectin I and L-18 levels were significantly correlated with liver function. 【Conclusion】 The determination of the changes of the two levels can be used to evaluate the liver function status and disease severity in patients with hepatitis B cirrhosis. It is also of value in judging the prognosis of patients with hepatitis B cirrhosis.