血管紧张素(angiotensin,Ang)(1-7)能改善心血管代谢综合征动物模型的血糖控制,但其作用的组织特异部位及这些代谢作用是否具有血压依赖性仍不明确。该研究假设Ang(1-7)通过促进外周葡萄糖转运来改善胰岛素敏感性。成年雄性C57BL/6J小鼠喂食标准饲料或60%高脂饲料11周。最后3周皮下输注Ang(1-7)400ng/(kg·min)或生理盐水,干预结束时行高胰岛素正葡萄糖钳夹检查。高脂喂食小鼠出现轻 Angiotensin (Ang) (1-7) improves glycemic control in animal models of cardiovascular metabolic syndrome, but its role in tissue-specific sites and whether these metabolic effects are blood pressure-dependent remain unclear. This study hypothesizes that Ang (1-7) improves insulin sensitivity by promoting peripheral glucose transport. Adult male C57BL / 6J mice were fed standard diet or 60% high-fat diet for 11 weeks. In the last 3 weeks, Ang (1-7) 400 ng / (kg · min) or saline was infused subcutaneously. At the end of the intervention, hyperinsulinemic positive glucose clamp examination was performed. High fat diet mice appear light