对~(99m)Tc-乙烯半胱氨酸二聚物、~(99m)Tc-六甲基丙烯胺肟及锝肟的~(99m)Tc-硼酸加合物等三类中性和脂溶性的~(99m)Tc络合物在脑中摄取和滞留的构效关系做了研究.这些新型~(99m)Tc脑灌注显像剂能用于各种脑血管异常的检测.尽管确切的截留机制及其与临床应用潜力的关系尚待阐明,但临床初步研究表明,~(99m)Tc制剂与~(123)I标记的脑灌注显像剂具有同样的临床效果. Three kinds of neutral and fat-soluble (99m) Tc-boric acid adducts such as ~ (99m) Tc-ethylene cysteine ​​dimer, ~99m Tc-hexamethonium amidoxime and ~ (99m) Tc complex in brain uptake and retention of the structure-activity relationship of these new ~ (99m) Tc cerebral perfusion imaging agent can be used for the detection of a variety of cerebrovascular abnormalities .Although the exact retention Mechanism and its relationship with the potential of clinical application remains to be elucidated. However, preliminary clinical studies have shown that ~ (99m) Tc preparation has the same clinical effect as ~ (123) I labeled brain perfusion imaging agent.