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早在十九世纪初叶Metchnikoff认为巨噬细胞是正常宿主一个重要防御系统。近些年来发现巨噬细胞除了吞噬异物、细菌和组织成分外,尚有很多其它重要功能,如:(1)刺激白细胞的干细胞生长;(2)产生并释放在不同宿主防御机制中很多活跃的体液物质,如补体、热原(pyrogen)、干扰素以及中性粒细胞化学趋向因子;(3)当体液免疫和细胞中介免疫反应时,以及在某种免疫病理过程中,与有免疫能力的淋巴样细胞相互作用;(4)产生和分泌相当数量的水解酶,中性蛋白酶(proteinase)以及溶菌酶;(6)产生并释放各种前列腺素和环状核苷酸;(7)破坏恶性细胞。特别是后一种机能,越来越受到人们的重视。目前不少研究把测定巨噬细胞的功能,作为一定肿瘤患者的免疫状态的客观指标之一。本文对不同肿瘤患者在化疗和放疗中其巨噬细胞吞噬功能进行观察,并观察了化疗和放疗对加服中草药冬凌草的患者的巨噬细胞机能的影响,以探讨巨噬细胞活动规律,以期对临床治疗提供一些有价值的资料。
As early as the early 19th century Metchnikoff considered macrophages an important defense system for normal hosts. In recent years, macrophages have found many other important functions besides phagocytosis of foreign bodies, bacteria and tissue components, such as: (1) Stimulation of leukocyte-derived stem cell growth; (2) Generation and release of many active Body fluids such as complement, pyrogen, interferons, and neutrophil chemotactic factors; (3) when humoral and cell-mediated immune responses, as well as in some immunopathological processes, are associated with immunogenic Lymphoid cells; (4) produce and secrete a significant amount of hydrolase, neutral proteinase and lysozyme; (6) produce and release various prostaglandins and cyclic nucleotides; (7) destroy malignant cell. Especially after a function, more and more people’s attention. At present, many studies determine the function of macrophages as one of the objective indicators of the immune status of certain cancer patients. In this paper, we observed the phagocytosis of macrophages in different tumor patients during chemotherapy and radiotherapy, and observed the effects of chemotherapy and radiotherapy on the macrophage function of Chinese herbal medicine Rubescens to investigate the activity of macrophages, In order to provide some valuable information for clinical treatment.