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采用大鼠心肌缺血再灌注模型观察黄芩甙对缺血再灌注后心律失常和心肌损伤的保护作用。实验大鼠分为假手术组、缺血再灌注组、黄芩甙I组、黄芩甙II组和维拉帕米组。观察对各组大鼠心电图、血清磷酸肌酸激酶(CPK)、谷胱甘肽过氧化物酶 (GSH PX)及心肌组织内超氧化物歧化酶 (SOD)、脂质过氧化物丙二醛 (MDA)的影响。结果表明 ,黄芩甙可显著减少再灌注性心律失常发生率 ,降低CPK活性和MDA含量 ,升高SOD和GSH PX活性。提示黄芩甙对再灌注心肌具有保护作用 ,其机制可能与其抗脂质过氧化反应有关
To observe the protective effects of astragalus on arrhythmia and myocardial injury after ischemia-reperfusion in rats. The rats were divided into sham operation group, ischemia reperfusion group, Huangqi I group, Huangqi II group and Verapamil group. Electrocardiogram, serum phosphocreatine kinase (CPK), glutathione peroxidase (GSH PX), superoxide dismutase (SOD) in myocardium, lipid peroxide malondialdehyde were observed in each group. (MDA) effect. The results showed that Astragalus can significantly reduce the incidence of reperfusion arrhythmia, reduce CPK activity and MDA content, and increase SOD and GSH PX activity. It is suggested that Astragalus has a protective effect on reperfusion of myocardium, and its mechanism may be related to its anti-lipid peroxidation reaction