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镇咳祛痰糖浆含有美沙芬氢溴酸盐(Ⅰ)、愈创木酚甘油醚(Ⅱ)、苯甲酸钠(Ⅲ)和糖精钠、着色剂、矫味剂、蔗糖、缓冲液等成分,药典法测定Ⅱ是以Ⅰ为内标的GLC,测定Ⅰ是经一系列提取洗涤后的分光光度法。目前报道的测定单方或复方咳嗽糖浆中Ⅰ、Ⅱ的HPLC法,均既不能同时测定两药,也不能克服Ⅰ保留时间长和拖尾的缺点。而本文所述的HPLC法则
Antitussive expectorant syrup with methadone hydrobromide (Ⅰ), guaifenesin (Ⅱ), sodium benzoate (Ⅲ) and sodium saccharin, coloring agents, flavoring agents, sucrose, buffers and other ingredients, Pharmacopoeia Method II is based on Ⅰ GLC, Ⅰ is determined by a series of extraction and washing after spectrophotometry. The currently reported HPLC methods for determination of I and II in unilaterally or in combination with cough syrups neither measure the two drugs simultaneously nor overcome the disadvantages of long retention times and tailing. The HPLC principles described in this article