论文部分内容阅读
为探讨吸烟与抗氧化类维生素及氧自由基的关系，我们检测了８７１例健康吸烟者和３４８例健康非吸烟者血浆维生素Ｃ（Ｐ－ＶＣ）、维生素Ｅ（Ｐ－ＶＥ）、β－胡萝卜素（Ｐ－β－ＣＡＲ）、过氧化脂质（Ｐ－ＬＰＯ）含量及红细胞超氧化物歧化酶（Ｅ－ＳＯＤ）活性。结果表明，与非吸烟组比较，吸烟组的Ｐ－ＶＣ、Ｐ－ＶＥ、Ｐ－β－ＣＡＲ、Ｅ－ＳＯＤ显著降低，Ｐ－ＬＰＯ显著升高；６５例相同年龄男性吸烟者的Ｐ－ＶＣ、Ｐ－ＶＥ、Ｐ－β－ＣＡＲ和Ｅ－ＳＯＤ均随吸烟史及吸烟量的增加而降低，Ｐ－ＬＰＯ随吸烟史及吸烟量的增加而升高，并均呈一定程度的直线相关；提示吸烟者体内的氧化和抗氧化平衡严重失调，氧自由基反应和脂质过氧化反应明显加剧。
To investigate the relationship between smoking and antioxidant vitamins and oxygen free radicals, we examined plasma vitamin C (P-VC), vitamin E (P-VE), β-carrot in 871 healthy smokers and 348 healthy non-smokers P-β-CAR, P-LPO and erythrocyte superoxide dismutase (E-SOD) activity. The results showed that P-VC, P-VE, P-β-CAR and E-SOD in smoking group were significantly lower and P-LPO significantly higher in smoking group than in non-smoking group , P-VE, P-β-CAR and E-SOD both decreased with the increase of smoking history and smoking history. P-LPO increased with the increase of smoking history and smoking history, and all showed a certain degree of linear correlation. Tip smokers body oxidation and antioxidant balance serious imbalance, oxygen free radical reaction and lipid peroxidation was significantly increased.