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目的:探讨氨氯地平联合阿托伐他汀治疗老年急性脑梗死高血压的临床疗效。方法:86例急性脑梗死高血压患者随机分为观察组与对照组,每组43例。对照组给予苯磺酸氨氯地平片5 mg,po,qd,观察组在对照组基础上加用阿托伐他汀片20 mg,po,qd。治疗1个月后比较两组患者疗效及神经功能缺损评分、血压、血脂、C反应蛋白(CRP)等指标变化情况。结果:治疗后,观察组急性脑梗死总有效率明显高于对照组(P<0.05);降压总有效率明显优于对照组(P<0.05)。治疗后两组神经功能缺损评分均明显高于治疗前(P<0.05),且观察组评分明显高于对照组(P<0.05)。两组患者血压均较前明显降低(P<0.05),且观察组较对照组下降更明显(P<0.05)。治疗后观察组TC、TG、LDL-C和CRP等指标水平较治疗前明显降低(P<0.05),也明显低于对照组(P<0.05)。结论:使用氨氯地平联合阿托伐他汀治疗老年急性脑梗死高血压,效果显著,不良反应少,值得推广应用。
Objective: To investigate the clinical efficacy of amlodipine and atorvastatin in the treatment of hypertension in elderly patients with acute cerebral infarction. Methods: A total of 86 patients with acute cerebral infarction and hypertension were randomly divided into observation group and control group, with 43 cases in each group. Control group was given amlodipine besylate tablets 5 mg, po, qd, the observation group in the control group based on the addition of atorvastatin tablets 20 mg, po, qd. One month after treatment, the curative effect, neurological deficit score, blood pressure, blood lipids and C-reactive protein (CRP) were compared between the two groups. Results: After treatment, the total effective rate of acute cerebral infarction in observation group was significantly higher than that in control group (P <0.05). The total effective rate of antihypertensive treatment was significantly better than that of control group (P <0.05). After treatment, the scores of neurological deficit in both groups were significantly higher than those before treatment (P <0.05), and the score of the observation group was significantly higher than that of the control group (P <0.05). Blood pressure in both groups was significantly lower than before (P <0.05), and the observation group than the control group decreased more significantly (P <0.05). The levels of TC, TG, LDL-C and CRP in the observation group after treatment were significantly lower than those before treatment (P <0.05), and also significantly lower than those in the control group (P <0.05). Conclusion: The combination of amlodipine and atorvastatin in the treatment of elderly patients with acute cerebral infarction has significant effect and few adverse reactions, which is worth popularizing and applying.