目的：测定褐家鼠的抗药性，观察抗凝血剂灭鼠效果。方法：抗药性调查，采用毒饵消耗法；灭效观察，采用３ｄ饱和投饵法。结果：济南市和许昌市部队驻地褐家鼠对杀鼠灵的抗药性发生率分别为２０４％和４１７％；潍坊市和辉县市虽未发现抗性鼠，但部分敏感褐家鼠个体对杀鼠灵的药物耐受性已经明显增强。溴敌隆、杀鼠迷和敌鼠钠盐３种抗凝血灭鼠剂对褐家鼠的实验室毒杀效果，无选择摄食试验毒杀率均为１００％；而有选择摄食试验毒杀率分别为９２８６％，６１５４％和３８４６％，摄食系数依次为０７０、０４５和０２２；现场灭鼠试验，溴敌隆和杀鼠迷毒饵盗食率明显高于敌鼠钠盐，灭鼠率则分别为８５１１％、８７３３％和８１５５％，三者间差异无显著性。结论：今后应加强抗药性监测，合理指导灭鼠用药，以减少褐家鼠抗药性的进一步发生 Objective: To determine the resistance of Rattus norvegicus and to observe the anti-coagulant effect of anti-coagulant. Methods: drug resistance survey, the use of bait consumption method; off observation, the use of 3d saturated feeding method. Results: The resistance rates of Rattus norvegicus to warfarin-resistant mice in Jinan and Xuchang were 2.04% and 417% respectively. Although Weifang and Huixian did not find resistant mice, some of them were sensitive brown House mouse individual drug resistance to warfarin has been significantly enhanced. Bromadiolone, warfarin and rivaroxaban 3 kinds of anticoagulant rodenticides on Rattus norvegicus laboratory poisoning effect, non-selective feeding test toxicity were 100%; and selective feeding test toxicity were 9286%, 6154% and 3846% respectively, and the feeding coefficients were 070, 045 and 022, respectively. On-site rodent control, Anti-rat sodium salt, rodent rate were 85  11%, 87  33% and 81  55%, no significant difference between the three. Conclusion: In the future, drug resistance monitoring should be strengthened to rationally guide the administration of rodent drugs to reduce further occurrence of brown drug resistance in Rattus norvegicus