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目的:观察甘草泻心汤在泮托拉唑四联疗法基础上治疗幽门螺杆菌(Hp)相关性胃溃疡的疗效,进一步分析患者短期复发率等。方法:回顾性选择钦州市第一人民医院于2015年3月2016年3月收治的86例Hp相关性胃溃疡患者,根据治疗方式不同分成观察组45例,对照组41例,对照组予以泮托拉唑四联疗法,观察组则同时应用甘草泻心汤。结果:观察组临床总有效率95.6%,胃镜总有效率88.9%,均高于对照组,P<0.05;观察组中医证候评分、溃疡面积均低于对照组,P<0.01;观察组Hp根除率显著高于对照组,P<0.05;观察组半年随访复发率低于对照组(P<0.01)。结论:泮托拉唑四联疗法治疗Hp相关胃溃疡的疗效尚可,同时辅以中药方甘草泻心汤能显著改善中医证候评分、减小溃疡面积,降低复发率,安全性高。
Objective: To observe the effect of Gancao Xiexin Decoction on the treatment of Helicobacter pylori (Hp) -related gastric ulcer based on the pantoprazole quadruple therapy and to further analyze the short-term recurrence rate of the patients. Methods: 86 cases of Hp-related gastric ulcer admitted to First People’s Hospital of Qinzhou City from March 2015 to March 2016 were retrospectively divided into observation group (45 cases) and control group (41 cases), and control group Torazole quadruple therapy, observation group is also applied licorice Xie Xin Tang. Results: The total effective rate of observation group was 95.6%, and the total effective rate of gastroscopy was 88.9%, all higher than that of control group (P <0.05). The scores of TCM syndrome and ulcer area in observation group were lower than those in control group (P <0.01) The eradication rate was significantly higher than that of the control group (P <0.05). The recurrence rate in the observation group was lower than that in the control group (P <0.01). Conclusion: The effect of pantoprazole quadruple therapy in the treatment of Hp-related gastric ulcer is acceptable. Simultaneously, the prescription of Gancao Xiexin Tang can significantly improve TCM syndrome score, reduce the ulcer area, reduce the recurrence rate and have high safety.