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自发现胰岛细胞抗体(ICA)以来,人们已普遍认为胰岛素依赖性糖尿病(IDDM)的发病与某种免疫异常有关。作者根据很多IDDM的发生是以病毒感染为契机的现象,测定了在病毒感染初期发挥重要作用的NK细胞活性,并进行了讨论。实验对象为32例IDDM患儿(男15、女17,年龄3～18岁)和与其年龄一致的32例健康人。患儿全部给与胰岛素治疗,由此产生的控制效果好的有15例,效果不好的有17例。并且由末梢血分离单核细胞作为效应细胞,用Na_2~ (51)CrO_4标记K-562培养细胞作
Since the discovery of islet cell antibodies (ICA), it has generally been accepted that the pathogenesis of insulin-dependent diabetes mellitus (IDDM) is associated with an immune disorder. Based on the fact that many IDDMs occur as a result of viral infection, the authors determined the NK cell activity that plays an important role in the early stages of viral infection and discussed. The subjects were 32 children with IDDM (15 males and 17 females, aged 3-18 years) and 32 healthy individuals of the same age. All children given insulin therapy, the resulting good control effect in 15 cases, the effect is not good in 17 cases. Monocytes were isolated from peripheral blood as effector cells and labeled with Na_2 51 CrO 4 for K-562 cells