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目的探讨虎杖对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)伴肺动脉高压患者的血流动力学及血栓素B2、6-酮-前列腺素F1α的影响,明确虎杖口服液的临床疗效。方法在我院住院病人中选取COPD伴肺动脉高压的急性期患者60例,随机分为对照组(32例)和虎杖组(28例)。对照组给予常规吸氧、抗感染、化痰、平喘等治疗共21 d,虎杖组在常规治疗基础上给予虎杖口服液每次l袋,每日2次,共用药21 d,各组治疗前后分别测定心率、体循环平均压、肺动脉压、血栓素B2、6-酮-前列腺素F1α。结果治疗后对照组的心率有显著改善(P<0.01),体循环平均压、肺动脉压、血栓素B2、6-酮-前列腺素F1α无明显改变;虎杖组的心率有显著改善(P<0.01),且较对照组无明显差异(P>0.05),体循环平均压无明显改善,肺动脉压有显著改善(P<0.05),血栓素B2显著下降(P<0.05),6-酮-前列腺素F1α增高(P<0.05)。结论虎杖口服液能降低COPD伴肺动脉高压患者的肺动脉压力,并能减少血栓素B2的产生,从而抑制血小板聚集和血栓形成。
Objective To investigate the effect of Polygonum cuspidatum on the hemodynamics and B2,6-keto-prostaglandin F1α of patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary hypertension and to determine the clinical efficacy of Polygonum cuspidatum oral solution. Methods Sixty patients with COPD and pulmonary hypertension were randomly divided into control group (n = 32) and Polygonum cuspidatum group (n = 28). The control group were given routine oxygen, anti-infection, phlegm, asthma and other treatment for 21 d, the Polygonum cuspidatum group was given on the basis of routine treatment of Polygonum cuspidatum oral l, 2 times a day, for 21 days, the treatment of each group Before and after the determination of heart rate, mean systemic pressure, pulmonary arterial pressure, thromboxane B2,6-keto-prostaglandin F1α. Results After treatment, the heart rate of the control group was significantly improved (P <0.01). The mean systemic pressure, pulmonary arterial pressure and thromboxane B2,6-keto-prostaglandin F1α had no significant change. The heart rate of the Polygonum cuspidatum group was significantly improved (P <0.01) (P <0.05). The mean systemic pressure had no significant improvement (P <0.05), the thromboxane B2 decreased significantly (P <0.05), the 6-keto-PGF1α Increased (P <0.05). Conclusion Polygonum cuspidatum oral liquid can reduce pulmonary artery pressure in patients with COPD and pulmonary hypertension, and can reduce the production of thromboxane B2, thereby inhibiting platelet aggregation and thrombosis.