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先前的研究已证明,应用 d1-高诺酮或 R-2323阴道环时,开始时血浆孕激素浓度较高,而后逐渐下降,不能获得满意的出血控制。本文作者研究了一种新型的阴道环,希望在应用的几个周期里能提供一种恒定的孕激素血浆浓度。避免了血液中甾体浓度迅速下降,应能获得良好的出血控制。这种阴道环是由一种硅酮聚合物制成的,环的中心为一个不含甾体的芯子,其上盖有一薄层浸有不同数量的dl-高诺酮的硅橡胶,最外层是硅胶管。作者设计了高释放率和中等释放率两种不同的阴道环,所用橡胶管的厚度为0. 305或0. 61毫米,环的外径6厘米,厚度9毫米。共有8名健康的育龄妇女参加了该研
Previous studies have shown that when d1-gonorolone or R-2323 vaginal rings are used, plasma progesterone concentrations are initially high and then declining gradually and satisfactory bleeding control can not be obtained. The authors studied a new type of vaginal ring that hopes to provide a constant plasma progesterone concentration over several cycles of application. Avoid the rapid decline of blood steroid concentrations should be able to get good bleeding control. The vaginal ring is made of a silicone polymer centered on a steroid-free core covered with a thin layer of silicone rubber impregnated with varying amounts of dl-gonadol, most The outer layer is silicone tube. The authors designed a high release rate and moderate release rate of two different vaginal rings, the thickness of the rubber tube used is 0. 305 or 0. 61 mm, the outer diameter of the ring 6 cm, the thickness of 9 mm. A total of eight healthy women of childbearing age participated in the study